Position Description:
The Department of Neurosurgery is seeking a highly-motivated candidate for a post-doctoral fellow position to work in translational research investigating the development of epilepsy and neuronal plasticity in a mouse model of temporal lobe epilepsy. Specific investigative aims include, i) genetic dysregulation in the temporal lobe, ii) structural plasticity during the development of epilepsy, iii) electrographic recording and stimulation of the brain in early epileptogenesis. Some of the techniques used in this project include animal stereotactic surgery, behavioral epilepsy scoring, microdissection, brain-slicing, DNA/RNA isolation, PCR, genotyping, whole animal electrocorticography, confocal microscopy. Transgenic mice lines will be used for scientific inquiry, future lines of investigation may include human post-surgical tissue. The candidate will join a vibrant neuroscience community with potential for additional opportunities in clinical and translational research. Potential candidates must have recently completed a neuroscience PhD or at least 2-years of postdoctoral training utilizing mouse models, and have experience with molecular biology. Application materials must provide a synopsis of mouse-related work completed, and list direct publications from mouse-related laboratory work. Primary Functions Knowledge - Skills - Abilities Required knowledge: PhD in neuroscience using mouse models, molecular biology, cell biology, structural biology, developmental biology or related disciplines, data interpretation, data analysis, statistics, documentation, records management, data utilization, complex problem solving, critical thinking, resource management, and writing/presentation skills Required skills and abilities: mouse handling and husbandry skills required, able to work independently and within a collaborative environment. Experience with stereotactic surgery, confocal-microscopy, electrophysiology, molecular biology techniques including immunohistochemistry, RNA isolation, western blot desirable.
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